Philip Reigan Selected Research

Therapeutics

1/2021	Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo.
1/2020	Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study.
1/2019	Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers.
1/2018	Development of Potent Pyrazolopyrimidinone-Based WEE1 Inhibitors with Limited Single-Agent Cytotoxicity for Cancer Therapy.
10/2016	Targeting WEE1 Kinase in Cancer.
4/2012	The role of glutathione in brain tumor drug resistance.

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Philip Reigan Research Topics

Disease

30	Neoplasms (Cancer) 08/2023 - 01/2003
4	Medulloblastoma 01/2018 - 03/2014
4	Pancreatic Neoplasms (Pancreatic Cancer) 07/2009 - 07/2006
3	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 09/2013
3	Breast Neoplasms (Breast Cancer) 06/2014 - 11/2005
3	Neoplasm Metastasis (Metastasis) 06/2014 - 01/2005
3	Leukemia 12/2013 - 05/2011
2	Inflammation (Inflammations) 04/2024 - 07/2012
2	Parkinson Disease (Parkinson's Disease) 04/2024 - 01/2021
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 12/2013
2	Thyroid Neoplasms (Thyroid Cancer) 01/2021 - 01/2019
2	Brain Neoplasms (Brain Tumor) 11/2020 - 04/2012
2	Hypoxia (Hypoxemia) 07/2020 - 03/2016
1	Gliosis 04/2024
1	Ovarian Neoplasms (Ovarian Cancer) 04/2023
1	COVID-19 01/2022
1	Infections 01/2022
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Lung Injury 01/2022
1	Neuroblastoma 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 11/2020
1	Myeloid Leukemia (Leukemia, Myelocytic) 07/2020
1	Anaplastic Thyroid Carcinoma 01/2019
1	follicular Thyroid cancer 01/2019
1	Papillary Thyroid Cancer 01/2019
1	Pleural Effusion (Pleural Effusions) 01/2019
1	Pituitary Neoplasms (Pituitary Adenoma) 03/2016
1	Lung Neoplasms (Lung Cancer) 12/2013
1	Necrosis 09/2013

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 04/2024 - 07/2006
7	Thymidine PhosphorylaseIBA 08/2023 - 01/2003
6	Phosphotransferases (Kinase)IBA 01/2018 - 03/2014
5	adavosertibIBA 01/2018 - 12/2013
5	EnzymesIBA 02/2013 - 01/2003
5	quinone (benzoquinone)IBA 05/2011 - 07/2006
4	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 03/2014
4	Oxidoreductases (Dehydrogenase)IBA 05/2011 - 07/2006
3	Glutathione (Reduced Glutathione)IBA 01/2021 - 04/2012
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 04/2016
3	Biomarkers (Surrogate Marker)IBA 12/2013 - 07/2009
3	IndolequinonesIBA 07/2009 - 05/2007
3	NAD (NADH)IBA 11/2007 - 07/2006
3	ProdrugsIBA 10/2006 - 01/2003
2	(11R,13S,17S)- 11- (1,3- benzodioxol- 5- yl)- 17- hydroxy- 13- methyl- 17- prop- 1- ynyl- 1,2,6,7,8,11,12,14,15,16- decahydrocyclopenta(a)phenanthren- 3- oneIBA 04/2024 - 01/2022
2	ThymidineIBA 01/2022 - 09/2013
2	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2022 - 11/2020
2	polypeptide 3 90kDa ribosomal protein S6 kinaseIBA 10/2021 - 01/2021
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 11/2016 - 02/2016
2	Small Interfering RNA (siRNA)IBA 04/2016 - 09/2013
2	AntioxidantsIBA 09/2013 - 04/2012
2	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 07/2012 - 05/2011
2	NRH - quinone oxidoreductase2IBA 08/2011 - 05/2011
2	Macrocyclic LactamsIBA 05/2011 - 10/2006
2	Antineoplastic Agents (Antineoplastics)IBA 01/2011 - 07/2009
2	indoleIBA 07/2009 - 07/2006
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 04/2024
1	SynucleinsIBA 04/2024
1	Neuroprotective AgentsIBA 04/2024
1	RotenoneIBA 04/2024
1	Peptides (Polypeptides)IBA 04/2023
1	AndrogensIBA 01/2022
1	DeoxyriboseIBA 01/2022
1	Triglycerides (Triacylglycerol)IBA 01/2022
1	GlucocorticoidsIBA 01/2022
1	Angiotensin-Converting Enzyme 2IBA 01/2022
1	Androgen Receptors (Androgen Receptor)IBA 01/2022
1	Serine Proteases (Serine Protease)IBA 01/2022
1	Lipoproteins (Lipoprotein)IBA 01/2022
1	diphenyl (biphenyl)IBA 01/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2022
1	CarbonIBA 01/2021
1	ManebIBA 01/2021
1	Temozolomide (Temodar)FDA LinkGeneric 01/2021
1	IsotopesIBA 01/2021
1	ZinebIBA 01/2021
1	nabamIBA 01/2021
1	SCH772984IBA 01/2021
1	Sulfhydryl Compounds (Thiols)IBA 01/2021
1	dabrafenibIBA 01/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2021
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2021
1	IsoxazolesIBA 11/2020
1	AmidesIBA 11/2020
1	Acetyl-CoA CarboxylaseIBA 07/2020
1	AMP-Activated Protein KinasesIBA 07/2020
1	OxindolesIBA 07/2020
1	90-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 90 kDa)IBA 01/2020
1	RacivirIBA 01/2019
1	pyrazolopyrimidinoneIBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2017
1	Cytotoxins (Cytolysins)IBA 04/2016
1	hesperadinIBA 03/2016
1	Transcription Factors (Transcription Factor)IBA 02/2016
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 06/2014
1	AntimetabolitesIBA 12/2013
1	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2013
1	Glutamate-Cysteine LigaseIBA 09/2013

Therapy/Procedure

7	Drug Therapy (Chemotherapy) 04/2023 - 01/2005
6	Therapeutics 01/2021 - 04/2012
1	Drug Tapering 04/2016